This module is an introduction to cellular biochemistry focusing on the core pathways of intermediary metabolism which are central to cellular function. Specifically, it focuses on two related and key areas of biochemistry. The first is enzymology; how do proteins function as biological catalysts and how are chemical reactions controlled within a cell? Students will investigate how the many chemical reactions which participate in metabolism are accurately regulated and organised.

The second is cellular metabolism; particularly, how do cells obtain energy from their surroundings to maintain their complex order?

The module will cover several seminal and Nobel Prize winning research topics including a detailed look at the key reactions of the citric acid cycle and the coupling of electron transport, proton pumping and ATP synthesis. The concepts and areas of biochemistry covered will be further illustrated by reference to the pathological state and human diseases which result from specific malfunctions in biochemical pathways and reactions.

This module explores the interactions that take place both within and between cells and which allow them to perform their function in the whole organism. Students will consider five key topics within cell biology:

• The methods used to study cells and the dynamic nature of the cytoskeleton
• The mechanisms and physiological significance of transport across membranes
• The mechanisms involved in cells receiving and acting upon information from outside of the cell
• The mechanisms of development of whole organisms, examining how individual cells become committed to a particular function as development occurs
• The regulation of the cell cycle, growth, and development. We will illustrate these topics using examples drawn from a range of biological system.

In this module you will develop knowledge and understanding of how the Biomedical Science discipline of Cellular Pathology is used to diagnose disease. Students will learn about different types of patient tissue samples and how these are fixed, processed and stained in order to identify diseased tissue. Students will gain practical experience with biomedical science colleagues from the Royal Lancaster Hospital during which they will stain, visualise and evaluate a range of samples in order to inform disease diagnosis.

This module explores core aspects of Clinical Biochemistry: Calcium Metabolism; Clinical Enzymology and Biomarkers; Liver Function Tests; Analysis of Serum Proteins; Endocrine system tests; Renal Function tests and Acid-Base regulation. Case studies will be used in order to apply new knowledge to real situations.

Practical work will enable students to: measure calcium and albumin in body fluids; carry out protein electrophoresis and measure enzyme activity. Each of these practical activities is based around case study scenarios, in order to demonstrate the value of these techniques in diagnosis.

The aim of this module is to provide students with the skills they need to begin their future careers. The module will enhance career awareness, develop oral communications skills and develop CV and cover letter writing. Workshops include sessions on LinkedIn, information skills, assessment centres, interview techniques and entrepreneurship.

This module takes a molecular approach to understanding heredity and gene function in organisms ranging from bacteria to man. It begins by reviewing genome diversity and how genomes are replicated accurately, comparing and contrasting replication processes in bacteria and man. The module discusses in detail molecular mechanisms, particularly those that ensure information encoded in the genome is transcribed and translated appropriately to produce cellular proteins.

Students will focus on the importance of maintaining genome stability and damaging effects of mutations in the genome on human health. Examples are drawn from a range of inherited genetic diseases such as phenylketonuria and sickle cell anaemia, paying particular focus to how mutations in key genes are driving cancer development.

Teaching is delivered by a series of lectures supported by varied practical work, workshops, guided reading and online resources. Laboratory practicals include investigating how exposure of bacteria to ultraviolet light induces mutations – providing a model for understanding how skin cancer may develop as a consequence of excessive sun exposure.

This module enables the investigation of the constituents of blood in a healthy individual and in a variety of diseased states. A range of blood disorders will be discussed, such as leukaemias and anaemias, leading to an understanding of a range of diagnostic tests.

The function of platelets in preventing blood loss and the blood coagulation cascade will be investigated. This knowledge will be used to enable understanding of a range of bleeding and coagulation disorders and their diagnosis and treatment. Common blood tests will be discussed and carried out in the laboratory sessions, with the emphasis upon accuracy, comparison of results with a normal reference range and safe working practice in the laboratory. A case study workshop is used to enable students to interpret data and apply theoretical understanding gained during this module.

This course examines the relationship between microbe and host; with particular focus on bacterial and viral pathogens. The diversity of structure, function and metabolism of bacteria, in relation to their role as a cause of disease, is explored and practical skills in bacteriology are introduced. Morphology and reproductive strategies of viruses are examined and methods for controlling viral infections by vaccination or anti-viral therapies are described. The course introduces principles of clinical microbiology by focusing on epidemiology, diagnosis, treatment of infection and host immune defences. The theme is one of "emergence" illustrating how some new infections have come to be a problem in health care and the importance of protective commensal microbes. The laboratory classes focus on diagnostic processes and illustrate the contribution which the microbiology laboratory can make to clinical decision making and epidemiology. This course also deals with the way in which pathogens (mainly bacteria) survive, and sometimes grow, in the environment and the implications this has for health in the community. The course is given in collaboration with health service consultants and workers from the University Hospitals of Morecambe Bay NHS Trust.

The aim of this module is to build on knowledge gained in earlier first year modules: Anatomy and Tissue Structure and Human Physiology. Students will focus on four weekly themes: heart and circulation; muscle and fatigue; nervous system and the urinary system. Students independently learn theoretical background information using online and text-based resources, supported by weekly case study discussions during seminars. Muscle electrical activity and fatigue, ECG and nerve conduction velocity will be explored through experimentation on student volunteers and online simulations.

The research project gives students first-hand experience of research and also the opportunity to be immersed in, and learn about, an area of work which is of current interest. Students plan, conduct and report on an open-ended investigation, often related to research interests of a member of staff. Projects cover a very wide variety of topics and may be carried out in a variety of ways. They involve a significant amount of original work and analysis to be carried out by students so that they gain experience in a range of skills, including experimental design and the testing of hypotheses. The results of the research are reported in an 8,000 word dissertation and an oral presentation.

In this module students are given an overview of the cellular and molecular processes that underpin the development of cancer. This will enable students to discuss the various factors that can affect cancer susceptibility. Students will look at the approaches taken to treat cancer, including some of the new generation of molecularly-targeted cancer therapies.

Every day our body does something remarkable, but we are completely unaware of it most of the time: our immune system is constantly protecting us from pathogens in our environment as well as threats from within. This highly evolved, interdependent collection of organs, cells and chemical messengers is continually scanning our tissues for any unwanted intruders or abnormal cells. When we get ill, with a cold for example, full mobilisation of our immune system sends armies of cells and molecules to fight the problem in what can sometimes literally be a fight to the death. Fortunately for us, our immune system wins the battle almost every time!

In this module we examine the various components of the immune system – the organs, cells, and messengers, and how they function in health and illness. We look at particular threats such as allergies, infectious diseases and cancer, providing students with a good understanding of how this vital component of our bodies keeps us well.

This module aims to provide an understanding of the organisation of the human genome, how disease genes are mapped and how mutations are identified leading to the development of diagnostic tests. The impacts of massively parallel next generation DNA sequencing, microarrays and SNP genotyping on gene discovery and disease diagnosis are examined. The application of modern genetic techniques to identifying susceptibility genes for complex, multifactorial traits will also be studied. A range of diseases will be examined in detail both in lectures and in case study workshop sessions. The final lecture looks at gene therapy and considers the future for treatment of genetic disorders. The practical session aims to give students an opportunity to study their own DNA in a forensics scenario, using techniques that are widely applicable in modern molecular genetics.

This course considers the aetiology, pathogenesis, diagnosis and treatment of some of the major chronic diseases (excluding cancer) that affect human health, including: neurodegenerative conditions like Alzheimer’s and Parkinson’s disease; osteoarthritis and rheumatoid arthritis; cerebrovascular disease; and the two major types of diabetes. Some of the lectures are delivered by experts who treat patients with these diseases in local hospitals. Teaching is through lectures, practical work, and group-based student discussions and presentations.

Talks given by the students themselves expand understanding to cover the pathobiology of many different chronic human diseases that are not covered formally in the lectures. There is also a practical class on diabetes that complements the lectures and teaches how some simple biochemical tests can be used for diagnosis and management of this condition.

The ability of cells to communicate with one another using signalling pathways is of fundamental importance in multicellular organisms such as mammals. Cell signalling enables the transmission of information that is required for the correct co-ordination of metabolism, growth and development.

This module revises the basic principles of cellular communication, exploring the molecular basis of signalling in detail by using key signalling pathways as examples. The combination of Lectures and Workshops allows students to evaluate influential scientific discoveries, whilst Laboratory practicals provide the opportunity to put theory into practice.

This module explores some of the key roles played by ion channels and calcium ions in the communication that takes place within and between cells. The module is split into two linked themes. Firstly, an introduction to the diversity of ion channel families and their biological functions including the many different cellular processes throughout the life history of cells that are regulated by calcium ions as signals. Secondly, an investigation of the importance of ion channels and calcium signalling in animals, and human physiology in particular, using examples of diseases that are caused when ion channels malfunction (e.g. myotonia, malignant hyperthermia, sudden heart arrest caused by long QT syndrome.) or calcium signalling is disrupted (e.g. Alzheimer’s disease, polycystic kidney disease, pancreatitis). Students also gain hands-on experience of the techniques used to study ion channels and calcium signalling in cells.

Research and practice in biomedicine continues to evolve more rapidly than at any other time in history, raising fascinating but complex moral and ethical challenges for those studying and working in the field. Understanding ethics in biomedicine and the relationship between science and society has become an essential element in biomedical degree training.

This module builds on the Biomedicine and Society module, aiming to help students develop a deeper understanding of key ethical principles used in biomedicine and some major cultural, social and political influences that define research agendas and fuel ethical debates in the public perception of biomedicine.

The module takes on a seminar format structured around three core themes:

• The development of ethical principles in biomedicine
• Ethical practice and current debates in animal and human research including clinical trials
• Ethical challenges such as those emerging in genetics and regenerative medicine and how these are debated in the media.

How is DNA, the fundamental building block of life, organised and expressed in different types of organisms such as bacteria and humans? Lectures comparing eukaryotic and prokaryotic gene organisation and expression, chromatin structure and DNA repair will seek to answer this question. In addition, students will study the application of genetics to science and technology during practical and workshop sessions, providing them with the opportunity to develop group and independent working skills whilst reinforcing theoretic concepts.

In this module students will work together as a team to propose a solution to a problem of biological relevance, for example antibiotic resistance, invasive species or healthy ageing. The solution may be a patentable, commercial product or a policy proposal. Weekly workshop sessions will be held for the whole class which will include presentations from external speakers on topics such as intellectual property, project management and negotiating skills. Each team will choose a leader who will be responsible for organising regular meetings in which ideas are developed, tasks assigned and information gathered. The team will produce a report in the form of a patent application or policy document which will form part of the module assessment. The remainder of the assessment will be based on an oral presentation. Peer-assessment will be used to adjust tutors' marks according to individual contribution to the project.

Students will be introduced to the importance of molecular, metabolic and cellular interactions within parasitic protists, and between a range of parasitic protists and their hosts.

The course will provide students with an understanding of how the life cycle strategies used by protists enable them to gain access to, and survive within, the host as well as the impact that protist parasites have on human health. Practicals will provide an opportunity for students to apply immunological skills to investigate the host-parasite interaction.

Nervous system function, from formation in the embryo to sensory systems and the neural control of complex behaviours, is the focus of this module. The emphasis is on model systems and the use of genetic tools to elucidate developmental pathways and neural circuits. Practical exercises are used to illustrate some of the functions of nervous systems and how these can be manipulated by genetic intervention.

Students are encouraged to access and evaluate information from a variety of sources and to communicate the principles in a way that is well-organised, topical, and recognises the limits of current hypotheses. On completion of the module, students will be equipped with practical techniques including data collection, analysis and interpretation.

Microbiology for the biomedical scientist comprises screening samples to identify and assess microbiological pathogens that cause disease and, enable front line medical staff to choose the correct therapy for successful eradication of the infection. Increasing numbers of these infections are community acquired and many are contracted from, or in, the environment. The environment therefore plays an increasing role in the life cycle and ecology of many pathogens. This in turn, is having an increasing impact on human health and national health services. The increase is a combination of changing environmental conditions (such as land use changes, global warming) and an ever evolving microbial community, most of which do not harm but a few can cause mild to fatal diseases when the opportunity arises. Also cycling in the environment are obligate pathogens which will cause infections if contracted. Furthermore, there are new diseases emerging (e.g. Ebola) and others thought to have been controlled are now re-emerging such as cholera. Using specific microbial pathogens as examples, this module examines the factors and interactions that allow microbial infections to be transmitted from the environment to humans and how their life cycle plays an important role in their emergence, persistence, transmission and infection. It also examines antibiotic resistance: how it has emerged, the different types of resistance, its management and the complications that it imposes on the treatment of these diseases.

Assessment:

1. Exam: 2 hour paper with two questions in sections A and B. Students are required to answer one question from each.

2. Coursework is an extended essay of 2000 words based on the lectures and field trip. The title will be announced in the first lecture.

Understanding how life works depends to a great extent on understanding how proteins work. Thanks to the Human Genome Project, we now have a catalogue of all the proteins that are encoded in the human genome. This might be thought of as life’s toolbox. The next questions are: how do those tools work; how do they interact with each other; and how have they evolved over the billions of years of evolutionary time that have led to us? This module introduces modern techniques for the study of protein structure, function and evolution.

Lectures cover: structural-functional relationships in proteins; methods for detecting the action of Darwinian selection in protein evolution; methods for reconstructing the evolutionary events that have led to present-day proteins; and, the new lab techniques that are allowing us to study protein function on a large scale. In the practical sessions, students will gain hands-on experience of molecular phylogenetics – the main tool for studying evolution at the molecular level – as it is applied to proteins. Assessment is by an exam and a coursework essay on a protein of your choice, giving students a chance to apply their new knowledge of protein biochemistry to any of their own areas of interest in biology.