CHIC 465/565 – Environmental Epidemiology

Chapter 6 Point Source Problems

Recall from Section 3.3 that a commonly-used model for spatial variation in risk is that:

  • λ(x)=αλ0(x)ρ(x) where

    • λ(x) is the intensity of the Poisson process forming the cases

    • λ0(x) is the intensity of the Poisson process forming the controls

    • α is determined by the number of controls in the design

    • ρ(x) represents spatial variation in risk

Conditional on both case and control locations, case/control labels are determined by a series of independent Bernoulli trials with success probabilities

p(x)=λ(x)λ(x)+λ0(x)=αρ(x)1+αρ(x). (6.1)

In Section 3.3 we looked at non-parametric models for ρ that could be used when no information other than the case and control locations was available. In this section we consider scenarios in which there is a hypothesised model for the spatial variation in risk ρ.