Dr Mohammed Rohaim
Senior Research AssociateResearch Overview
My primary focus revolves around comprehending the innate immune responses across various hosts, spanning from virus detection to the terminal interferon-mediated effects facilitated by an array of interferon-stimulated and virus-regulated genes. Utilizing expansive, genome-wide, and high-throughput screening platforms, my research aims to elucidate the distinct host reactions to various viral pathogens and grasp the underlying factors influencing genetic resistance or susceptibility across different species. This involves investigating virus-host cell interactions, particularly the mechanisms by which both viral and cellular components modulate the viral replication cycle and counteract the innate immune response. Additionally, through the application of genome-wide transcriptomics and proteomics methodologies, my work delves into unraveling the molecular determinants of viral pathogenesis and elucidating how viruses, such as influenza and coronaviruses, have evolved to evade the host's innate immunity. Another aspect of my research involves exploring the evolution of RNA viruses and delineating the functional significance of evolutionary alterations in terms of virus antigenicity, virulence, transmission dynamics, and host range expansion. Furthermore, I strive to enhance vaccine development and vaccination strategies for effective virus control, as well as to develop reagents and assays for rapid detection and differentiation of virus subtypes.
Diagnostic challenges of mixed infections with major poultry respiratory viruses (AIVs, NDV and IBV) in Egypt
01/07/2019 → 30/06/2021
Research
Control of Multiple Respiratory Viral Infections in Poultry
03/06/2019 → 30/06/2022
Research
Establishing Field Data-Driven Universal Influenza Vaccine Platform in Poultry: Step Towards Poverty Alleviation & Food security in Egypt
30/12/2018 → …
Research
Continuous Evolution of Newcastle Disease Virus under Mixed Infection with Other Respiratory Viruses in the Egyptian Poultry Flocks During 2014
25/10/2015 → 01/10/2017
Research
The 2nd International Electronic Conference on Vaccines
Participation in conference -Mixed Audience
Journal of Virological Sciences (Journal)
Editorial activity
Innovative Vaccine Platforms: Empowering Animal Immunity
Symposium
Frontiers in cellular and infection microbiology (Journal)
Editorial activity
Global Alliance for Research on Avian Diseases (GARAD) - One Health Poultry
Participation in conference -Mixed Audience
Zoonotic Diseases (Journal)
Editorial activity
Discover Viruses (Journal)
Editorial activity
Viruses (Journal)
Editorial activity
Pathogens (Journal)
Editorial activity
Animals (Journal)
Editorial activity
Journal of Molecular Pathology (Journal)
Editorial activity
8th International Conference of the Egyptian society of Virology
Participation in conference -Mixed Audience
Fish viral diagnostics and Vaccine advancements
Symposium
UK International Coronavirus Network (External organisation)
Membership of network
Frontiers in Microbiology (Journal)
Editorial activity
UK International Coronavirus Network (External organisation)
Membership of network
Frontiers in virology (Journal)
Editorial activity
Public Media interview on CoVID-19 and Zoonotic viruses
Other
Multidisciplinary Digital Publishing Institute (MDPI) (Publisher)
Editorial activity
Advances in Animal and Veterinary Sciences (Journal)
Editorial activity
The International Veterinary Vaccinology Network (External organisation)
Membership of network
Hosts and Viruses (Journal)
Editorial activity
World Society of Virology (External organisation)
Membership of network
Egyptian Society of Virology (External organisation)
Membership of board