Dr Matt Hodges
Physiological Services Facility Manager, Laboratory Safety OfficerResearch Overview
I spent my undergraduate years at UCL studying Human Genetics and went onto Imperial College London as a postgraduate and postdoctorial scientist (Biochemistry building, Sir Alexander Fleming building, Charing Cross Hospital and the MRC clinical Sciences Centre).
I am now a Facility Manager and the BLS Laboratory Health and Safety Officer.
Research Interests
Prior to coming to Lancaster my research interests were involved in the molecular biology aspects of human disease. Firstly in identifying genes subjected to methylation via the process of genetic imprinting in Beckwith-Wiedemann syndrome and trying to understand the mechanism in women who have familial recurrant hydatidiform mole. Secondly I have worked on vision, specifically trying to understand the mechanisms of how inherited mutations affect genes function and how functionality can be preserved in affected cells via neuroprotection delivered by stem cell therapy.
Current Research
I have downed my pipettors permanently now.
Selected Publications
Loss of angiotensin-converting enzyme-related (ACER) peptidase disrupts behavioural and metabolic responses to diet in Drosophila melanogaster
Glover, Z., Hodges, M.D.J., Dravecz, N., Cameron, J., Askwith, H., Shirras, A.D., Broughton, S.J. 25/04/2019 In: Journal of Experimental Biology. 222, 8, 12 p.
Journal article
Intestinal epithelial suppressor of cytokine signaling 3 (SOCS3) impacts on mucosal homeostasis in a model of chronic inflammation.
Shaw, E.J., Smith, E., Whittingham-Dowd, J.K., Hodges, M.D.J., Else, K.J., Rigby, R.J. 09/2017 In: Immunity, Inflammation and Disease. 5, 3, p. 336-345. 10 p.
Journal article
The Drosophila insulin receptor independently modulates lifespan and locomotor senescence
Hodges, M., Haji Ismail, M.Z.B., Boylan, M., Achall , R., Shirras, A., Broughton, S. 28/05/2015 In: PLoS ONE. 10, 5, 21 p.
Journal article
Differential regulation of E-cadherin expression by the soluble ectodomain and intracellular domain of jagged1
Delury, C., Tinker, C., Rivers, S., Hodges, M., Broughton, S., Parkin, E. 2/08/2013 In: International Journal of Biochemistry Research and Review. 3, 4, p. 278-290. 13 p.
Journal article
Combining immunolabeling and surface-enhanced Raman spectroscopy on cell membranes
Hodges, M., Kerns , J., Bentley, A.J., Fogarty, S., Patel, I.I., Martin, F.L., Fullwood, N.J. 12/2011 In: ACS Nano. 5, 12, p. 9535-9541. 7 p.
Journal article
Ex vivo gene therapy using intravitreal injection of GDNF-secreting mouse embryonic stem cells in a rat model of retinal degeneration
Gregory-Evans, K., Chang, F., Hodges, M., Gregory-Evans, C.Y. 13/05/2009 In: Molecular Vision. 15, p. 962-973. 12 p.
Journal article
Identification of 13 novel NLRP7 mutations in 20 families with recurrent hydatidiform mole; missense mutations cluster in the leucine-rich region
Wang, C.M., Dixon, P.H., Decordova, S., Hodges, M., Seibre, N.J., Ozalp, S., Fallahian, M., Sensi, A., Ashrafi, F., Repiska, V., Zhao, J., Xiang, Y., Savage, P.M., Seckl, M.J., Fisher, R.A. 25/02/2009 In: Journal of Medical Genetics. 46, 8, p. 569-575. 7 p.
Journal article
Systemic aminoglycoside treatment in rodent models of retinitis pigmentosa
Guerin, K., Gregory-Evans, C.Y., Hodges, M., Moosajee, M., Mackay, D.S., Gregory-Evans, K., Flannery, J.G. 09/2008 In: Experimental Eye Research. 87, 3, p. 197-207. 11 p.
Journal article
A clearer view of stem cells in retinal disease
Hodges, M., Gregory-Evans, C.Y., Gregory-Evans, K. 2008 In: Stem cell repair and regeneration. London : Imperial College Press p. 227-245. 19 p. ISBN: 978-1-86094-980-7 . Electronic ISBN: 978-1-908979-02-5.
Chapter
SNP genome scanning localizes oto-dental syndrome to chromosome 11q13 and microdeletions at this locus implicate FGF3 in dental and inner-ear disease and FADD in ocular coloboma.
Gregory-Evans, C.Y., Moosajee, M., Hodges, M., Mackay, D.S., Game, L., Vargesson, N., Bloch-Zupan, A., Rüschendorf, F., Santos-Pintos, L., Wackens, G., Gregory-Evans, K. 2007 In: Human Molecular Genetics. 16, 20, p. 2482-2493. 12 p.
Journal article
Evaluation of deletions in 7q11.2 and 8p12-p21 as prognostic indicators of tumour development following molar pregnancy
Burke, B., Sebire, N.J., Moss, J., Hodges, M., Seckl, M.J., Newlands, E.S., Fisher, R.A. 11/2006 In: Gynecologic Oncology. 103, 2, p. 642-648. 7 p.
Journal article
Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans
Aitman, T.J., Dong, R., Vyse, T.J., Norsworthy, P.J., Johnson, M.D., Smith, J., Mangion, J., Roberton-Lowe, C., Marshall, A.J., Petretto, E., Hodges, M., Bhangal, G., Patel, S.G., Sheehan-Rooney, K., Duda, M., Cook, P.R., Evans, D.J., Domin, J., Flint, J., Boyle, J.J., Pusey, C.D., Cook, H.T. 16/02/2006 In: Nature. 439, p. 851-855. 5 p.
Journal article
Familial recurrent hydatidiform mole: a review
Fisher, R.A., Hodges, M., Newlands, E.S. 08/2004 In: Journal of Reproductive Medicine. 49, 8, p. 595-601. 7 p.
Journal article
Genomic imprinting in gestational trophoblastic disease: a review
Fisher, R.A., Hodges, M. 04/2003 In: Placenta. 24, Suppl. A, p. s111-s118. 8 p.
Journal article
Genetic refinement and physical mapping of a biparental complete hydatidiform mole locus on chromosome 19q13.4.
Hodges, M., Rees, H.C., Seckl, M.J., Newlands, E.S., Fisher, R.A. 2003 In: Journal of Medical Genetics. 40, 8, 6 p.
Journal article
Characterization of the genomic and transcriptional structure of the CRX gene: substantial differences between human and mouse.
Hodges, M., Vieira, H., Gregory-Evans, K., Gregory-Evans, C.Y. 11/2002 In: Genomics. 80, 5, p. 531-542. 12 p.
Journal article
The maternally transcribed gene p57KIP2 (CDNK1C) is abnormally expressed in both androgenetic and biparental complete hydatidiform moles
Fisher, R.A., Hodges, M., Rees, H.C., Seibre, N.J., Seckl, M.J., Newlands, E.S., Genest, D.R., Castrillon, D.H. 2002 In: Human Molecular Genetics. 11, 26, p. 3267-3272. 6 p.
Journal article
Characterisation of the CRX Gene; Identification of Alternatively Spliced 5’ Exons and 3’ Sequence
Hodges, M., Gregory-Evans, C. 2001 In: New insights into retinal degenerative diseases. New York : Kluwer Academic Publishers p. 71-86. 16 p. ISBN: 0-306-46679-1.
Chapter
Temporal and spatial expression patterns of the CRX gene and its downstream targets: critical differences during human and mouse eye development
Bibb, L.C., Holt, J.K.L., Tarttelin, E.E., Hodges, M., Gregory-Evans, K., Rutherford, A., Lucas, R.J., Sowden, J.C., Gregory-Evans, C.Y. 2001 In: Human Molecular Genetics. 10, 15, p. 1571-1579. 9 p.
Journal article
Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome.
Alders, M., Ryan, A., Hodges, M., Bliek, J., Feinberg, A.P., Privitera, O., Westerveld, A., Little, P.F.R., Mannens, M. 05/2000 In: American Journal of Human Genetics. 66, 5, p. 1473-1484. 12 p.
Journal article
A human p57KIP2 transgene is not activated by passage through the maternal mouse germline
John, R.M., Hodges, M., Little, P., Barton, S.C., Surani, M.A. 1999 In: Human Molecular Genetics. 8, 12, p. 2211-2219. 9 p.
Journal article
Genomic organization and chromosomal localization of a member of the MAP kinase phosphatase gene family to human chromosome 11p15.5 and a pseudogene to 10q11.2.
Nesbit, M.A., Hodges, M., Campbell, L., de Meulemeester, T.M.A.M.O., Alders, M., Rodriques, N.R., TAlbot, K., Theodosiou, A.M., Mannens, M.A., Nakamura, Y., Little, P.F.R., Davies, K.E. 1/06/1997 In: Genomics. 42, 2, p. 284-294. 11 p.
Journal article
The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts.
Alders, M., Hodges, M., Hadjantonakis, A., Postmus, J., van Wijk, I., Bliek, J., de Meulemeester, M., Westerveld, A., Guillemot, F., Oudejans, C., Little, P., Mannens, M. 06/1997 In: Human Molecular Genetics. 6, 6, p. 859-867. 9 p.
Journal article
All Publications
- BLS Technical Staff