Research Overview

My group uses a range of methods, with solid-state NMR spectroscopy at the centre, to help understand the molecular mechanisms of human disease. Current active areas of research are:

1. The role of high-density lipoprotein (HDL) in cardiovascular disease. In collaboration with Blackpool Victoria Hospital, we are aiming to understand how HDL – or “good cholesterol” - can become dysfunctional and potentially contribute to the progression of atherosclerosis.
2. New methods for delivering therapeutic natural products. We are developing and analysing solid lipid nanoparticles to capture polyphenols from olive oil and other sources, and to facilitate in vivo delivery for the treatment of cardiovascular and neurodegenerative disorders. (See Alaziqi et al., ACS Omega, 2024.)
3. Development of NMR methods to understand how disease-associated amyloid fibrils interact with physiological and pharmacological ligands. (See Middleton, Prog. Magn. Reson. Spect., 2024.

The long-term aim is to develop new diagnostics and prototype therapeutics for cardiovascular disease and neurodegenerative disorders.